| Rank | Player | Att | RuYard | RuTD | Rec | ReYard | FPTS |
|---|---|---|---|---|---|---|---|
| 1 |
Christian McCaffreyC. McCaffrey
SF - RB |
245 | 1244 | 11 | 71 | 574 | 347 |
| 2 |
Breece HallB. Hall
NYJ - RB |
235 | 965 | 8 | 74 | 636 | 318 |
| 3 |
Bijan RobinsonB. Robinson
ATL - RB |
204 | 942 | 5 | 64 | 543 | 279 |
| 4 |
Saquon BarkleyS. Barkley
PHI - RB |
258 | 1065 | 10 | 45 | 361 | 270 |
| 5 |
Jonathan TaylorJ. Taylor
IND - RB |
286 | 1296 | 10 | 36 | 271 | 257 |
| 6 |
Kyren WilliamsK. Williams
LAR - RB |
247 | 1192 | 11 | 32 | 259 | 253 |
| 7 |
Alvin KamaraA. Kamara
NO - RB |
210 | 826 | 5 | 73 | 511 | 247 |
| 8 |
Derrick HenryD. Henry
BAL - RB |
282 | 1172 | 11 | 27 | 215 | 246 |
| 9 |
Travis EtienneT. Etienne
JAX - RB |
224 | 979 | 9 | 44 | 404 | 242 |
| 10 |
Jahmyr GibbsJ. Gibbs
DET - RB |
175 | 834 | 9 | 61 | 396 | 242 |
| 11 |
Josh JacobsJ. Jacobs
GB - RB |
246 | 1119 | 8 | 35 | 294 | 234 |
| 12 |
Joe MixonJ. Mixon
HOU - RB |
236 | 984 | 8 | 41 | 315 | 231 |
| 13 |
Rachaad WhiteR. White
TB - RB |
224 | 917 | 6 | 48 | 408 | 231 |
| 14 |
Isiah PachecoI. Pacheco
KC - RB |
229 | 958 | 9 | 45 | 278 | 227 |
| 15 |
Devon AchaneD. Achane
MIA - RB |
162 | 812 | 7 | 43 | 344 | 221 |
| 16 |
Aaron JonesA. Jones
MIN - RB |
183 | 887 | 5 | 50 | 394 | 214 |
| 17 |
Kenneth Walker IIIK. Walker III
SEA - RB |
236 | 897 | 9 | 29 | 234 | 210 |
| 18 |
James CookJ. Cook
BUF - RB |
215 | 936 | 4 | 44 | 383 | 210 |
| 19 |
Rhamondre StevensonR. Stevenson
NE - RB |
191 | 805 | 5 | 48 | 324 | 209 |
| 20 |
Austin EkelerA. Ekeler
WSH - RB |
134 | 638 | 6 | 49 | 429 | 202 |
